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Rho Family GTPases

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The Rho family of small GTP-binding proteins comprises a group of signaling molecules that are activated by a variety of Growth factors, Cytokines, Adhesion molecules, Hormones, Integrins, G-proteins and other biologically active substances and regulate a wide range of biological processes, including Reorganization of the Actin Cytoskeleton, Transcriptional Regulation, Vesicle Trafficking, Morphogenesis, Neutrophil activation, Phagocytosis and activation of the NADPH Oxidase, Mitogenesis, Apoptosis and Tumorigenesis. The mammalian Rho GTPase family currently consists of three subfamilies, Rho (RhoA, RhoB and RhoC), Rac (Rac1, Rac2 and Rac3) and CDC42 (Cell Division Cycle-42) (CDC42Hs and G25K). The best-characterized family members of Rho Family GTPase are RhoA, Rac1 and CDC42. Each controls the formation of a distinct cytoskeletal element in mammalian cells. Activation of [...]


1.Rho GTPases at the crossroad of signaling networks in mammals.
Hervé JC, Bourmeyster N.
Small GTPases. 2015;6(2):43-8. doi: 10.1080/21541248.2015.1044811. Epub 2015 Jun 25. No abstract available.
2.Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells.
Nayak RC, Chang KH, Vaitinadin NS, Cancelas JA.
Immunol Rev. 2013 Nov;256(1):255-68. doi: 10.1111/imr.12119. Review.
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