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RhoA Pathway

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Description

Rho is a member of the Ras superfamily of small GTP-binding proteins that play a central role in diverse biological processes such as Actin cytoskeleton organization, Microtubule dynamics, Gene transcription, Oncogenic transformation, Cell cycle progression, Adhesion and Epithelial wound repair. To date, 20 genes encoding different members of the Rho family have been identified in the human genome, and each one acts as a molecular switch to control distinct biochemical pathways. The mammalian Rho GTPase family currently consists of three subfamilies, Rho (RhoA, RhoB and RhoC), Rac (Rac1, Rac2 and Rac3) and CDC42 (Cell Division Cycle-42) (CDC42Hs and G25K). Rho proteins cycle between an active GTP-bound state and an inactive GDP-bound state. Their activation state is controlled by regulatory proteins [...]

References:

1.Regulation of Rho proteins by phosphorylation in the cardiovascular system.
Loirand G, Guilluy C, Pacaud P.
Trends Cardiovasc Med. 2006 Aug;16(6):199-204.
2.A dual role for RhoA in suppression and induction of cytokines in the human neutrophil.
Fessler MB, Arndt PG, Just I, Nick JA, Malcolm KC, Worthen GS.
Blood. 2006 Oct 3;
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