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RhoGDI Pathway

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Description

The Rho family of small GTPase proteins comprises CDC42 (Cell Division Cycle-42), Rac, and Rho. Proteins of the Rho/Rac subfamily (Rho proteins) of small GTP-binding proteins function as molecular switches that regulate a multitude of biological processes including cell proliferation, apoptosis, differentiation, migration, cytoskeletal reorganization, and membrane trafficking. Like most of the Ras-related proteins, Rho GTPases cycle between an inactive GDP-bound conformation and an active GTP- bound conformation. Cycling between the two conformations enables these proteins to act as binary switches (Ref.1). The tightly regulated GTP-binding/GTPase cycle requires the coordinated action of three regulatory proteins: 1) GEFs (Guanine Nucleotide Exchange Factors), which stimulate the GTP–GDP exchange reaction; (2) GAPs (GTPase-Activating Proteins), which stimulate the GTP-hydrolytic reaction; and (3) GDIs (Guanine Nucleotide Dissociation Inhibitors), which antagonize the [...]

References:

1.Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI.
Del Pozo MA, Kiosses WB, Alderson NB, Meller N, Hahn KM, Schwartz MA.
Nat Cell Biol. 2002 Mar;4(3):232-9.
2.Molecular characterization of the Caenorhabditis elegans Rho GDP-dissociation inhibitor.
Seow F. Yap, Weining Chen, and Louis Lim.
Eur J Biochem. 1999 Dec;266(3):1090-100.
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