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S-1P Stimulated Signaling

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Various lipid molecules serve as second messengers for transducing signals from the cell surface to the cell interior and trigger specific cellular responses. Sphingolipids represent a complex group of lipids that have recently emerged as new transducers in eukaryotic cells. Sphingolipids are found in all mammalian cells and are mostly located in the plasma membrane. They all contain as a backbone a long-chain base – the sphingoid base (mostly sphingosine) – linked to a fatty acid by an amide bond, thus forming ceramide. Addition of a phosphocholine substituent or sugar to ceramide gives rise to the major sphingolipid SM (sphingomyelin) or to glycosphingolipids, respectively. Ceramide is also produced by breakdown of all sphingolipids by glycosidases (for glycolipid degradation) and Sphingomyelinases. [...]


1.Enzymes of sphingolipid metabolism: from modular to integrative signaling.
Hannun YA, Luberto C, Argraves KM
Biochemistry. 2001 Apr 24; 40(16):4893-903. Review.
2.Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation.
Pitson SM, Moretti PA, Zebol JR, Lynn HE, Xia P, Vadas MA, Wattenberg BW.
EMBO J. 2003 Oct 15; 22(20):5491-500.
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