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SMAD Signaling Network

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


TGF-Beta (Transforming Growth Factor-Beta) superfamily of secreted polypeptide growth factors play an important role in a variety of pathophysiologic processes, including angiogenesis, vascular remodeling, atherogenesis and in regulating cellular responses such as growth, proliferation, differentiation, migration, adhesion, survival, and specification of developmental fate. Apart from TGF-Beta, the superfamily also includes the Activins, NODAL and the BMPs (Bone Morphogenetic Proteins). These factors signal through heteromeric complexes of Type-II and Type-I serine-threonine kinase receptors, which activate the downstream SMAD (Sma and Mad Related Family) signal transduction pathway (Ref.1, 2 & 3).Based on their structures and known functional roles, the mammalian SMAD family members fall into at least three broad classes: (i) the CO-SMADS (SMAD4) (ii) the R-SMADs (SMAD1, SMAD2, SMAD3, SMAD5, and [...]


1.Structural basis of Smad2 recognition by the Smad anchor for receptor activation.
Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massagué J, Shi Y.
Science. 2000 Jan 7; 287(5450):92-7.
2.Structural basis for a functional antagonist in the transforming growth factor beta superfamily.
Cook RW, Thompson TB, Kurup SP, Jardetzky TS, Woodruff TK.
J Biol Chem. 2005 Dec 2; 280(48):40177-86. Epub 2005 Sep 26.
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