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SOCS Pathway

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SOCS (Suppressor of Cytokine Signaling) proteins attenuate Cytokine and Tyrosine Kinase receptor signaling pathways (including those that regulate the immune system) by providing a negative feedback signal to prevent excessive cellular activation that can be lethal. The SOCS proteins regulate signal transduction by combining direct inhibitory interactions with cytokine and/or TYK receptors and signaling proteins such as the JAKs (Janus Kinases), STATs (Signal Transducer And Activator Of Transcription) or IRS (Insulin Receptor Substrates) family members, with a generic mechanism of targeting associated proteins for degradation by the proteasome (Ref.1).

The SOCS family (also termed as: SSI [STAT-induced STAT Inhibitors], CIS [Cytokine Inducible SH2 containing protein], and JAB [JAK Binding Protein]) contains eight members, SOCS1 through SOCS7 and CIS, each of [...]


1.Suppressors of cytokine signaling (SOCS) in the immune system.
Alexander WS.
Nat Rev Immunol. 2002 Jun; 2(6): 410-6. Review.
2.Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance.
Mooney RA, Senn J, Cameron S, Inamdar N, Boivin LM, Shang Y, Furlanetto RW.
J Biol Chem. 2001 Jul 13; 276(28): 25889-93.
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