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STAT3 Pathway

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STATs (Signal Transducers and Activators of Transcription) are a family of cytoplasmic proteins with SH2 (Src Homology-2) domains that act as signal messengers and transcription factors and participate in normal cellular responses to Cytokines and GFs (Growth Factors). STATs are activated via the tyrosine phosphorylation cascade after ligand binding and stimulation of the Cytokine Receptor–Kinase complex and Growth Factor-Receptor complex like the EGF (Epidermal Growth Factor), FGF (Fibroblast Growth Factor), PDGF (Platelet-Derived Growth Factor), GCSF (Granulocyte Colony Stimulating Factor), IL-6 (Interleukin-6), CNTF (Ciliary Neurotrophic Factor), OSM (Oncostatin-M), LIF (Leukemia Inhibitory Factor), CSF1R (Colony Stimulating Factor-1 Receptor), c-kit, Insulin receptor, c-Met and GPCRs (G-Protein Coupled Receptors): AgtR2 (Angiotensin-II Receptor). Ligands signaling through the same class of receptor complexes usually activates the same set of STAT factors, e.g. all IL-6-type cytokines activate STAT3 and STAT1 (Ref.1). The activated STATs are subsequently translocated to the [...]


1.The Jak/Stat pathway: a novel way to regulate PI3K activity.
Abell K, Watson CJ.
Cell Cycle. 2005 Jul; 4(7):897-900. Epub 2005 Jul 11.
2.Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2.
Ji JD, Kim HJ, Rho YH, Choi SJ, Lee YH, Cheon HJ, Sohn J, Song GG.
Rheumatology (Oxford). 2005 Aug; 44(8):983-8. Epub 2005 Apr 19.
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