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Salmonella Infection

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Phagocytic cells are a critical line of defense against infection. The ability of a pathogen to survive and even replicate within phagocytic cells is a potent method of evading the defense mechanisms of the host. A number of pathogens survive within macrophages after phagocytosis and this contributes to their virulence. Salmonella is one of these pathogens. Salmonella spp are Gram-negative bacteria capable of infecting a wide range of host species, including humans, domesticated and wild mammals, reptiles, birds and insects. They are the etiologic agents of a variety of diseases globally defined as salmonellosis. Salmonellosis is one of the most important human enteric diseases worldwide. Salmonella infections display a broad range of clinical manifestations that are dependent on both the [...]


1.Macrophage killing is an essential virulence mechanism of Salmonella typhimurium.
1. Lindgren SW, Stojiljkovic I, Heffron F.
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4197-201.
2.Striking a balance: modulation of the actin cytoskeleton by Salmonella.
Galan JE, Zhou D.
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8754-61.
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