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Description |
Phosphatidylserine (or 1, 2-Diacyl-sn-Glycero-3-Phospho-L-Serine) is the only
amino acid-containing glycerophospholipid in animal cells. Although it is
distributed widely among animals, plants and microorganisms, it is usually less
than 10% of the total phospholipids, the greatest concentration being in myelin
from brain tissue. It is an acidic (anionic) phospholipid with three ionizable
groups, i.e. the phosphate moiety, the amino group and the carboxyl function. As
with other acidic lipids, it exists in nature in salt form.
In bacteria
and other prokaryotic organisms, Phosphatidylserine is synthesized by a
mechanism comparable to that of other phospholipids, i.e. by reaction of
L-Serine with CDP-DAG (CDP-Diacylglycerol).In contrast in animal tissues, there
are two routes to Phosphatidylserine involving distinct enzymes: PS Synthase
(Phosphatidylserine-I and II), and Phosphatidylserine [...] |
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