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Description |
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The semaphorins are a family of growth cone guidance molecules, conserved from
insects to mammals, which includes proteins strongly implicated in mediating
repulsive guidance during neurodevelopment and neuronal regeneration. The range
of neurons responsive to semaphorins is extensive and includes dorsal root
ganglion, sympathetic, motor, cerebellar, hippocampal, olfactory and
corticospinal neurons. Currently, more than 20 members have been identified and
they all share a conserved, 500 amino acid residue Sema domain near their amino
terminus. Semaphorins are divided into eight classes according to species of
origin and structural similarities. The best characterized class of the
Semaphorin family is Class 3 Semaphorins. Currently, six members have been
identified (Sema3A–F), which has been implicated in cell migration, tumor growth
and the immune [...] |
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