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Sertoli-Sertoli Cell Junction Dynamics

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Description

The Blood-Testes Barrier (abbreviated as BTB) acts as a physical barrier between the blood vessels and the seminiferous tubules of the testes. This barrier is formed by tight and adherens connections between the Sertoli cells, which are sustentacular cells (supporting cells) of the seminiferous tubules, and nourish the spermatogonia (Ref.1). In the testis, tight and adherens junctions are dynamically remodeled to allow the movement of post-meiotic germ cells across the seminiferous epithelium and the timely release of spermatids into the tubular lumen. Three main functions are ascribed to the blood-testis barrier; (i) creates a specialized environment; (ii) regulates the passage of molecules; and (iii) serves as an immunological barrier. When the blood-testes barrier is breached, and sperm enters the bloodstream, [...]

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