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Description |
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T cell responses against tumors require the recognition of specific peptides
derived from tumor antigens in association with MIC (MHC Class I Molecules) by
CD81 T cells expressing
TCRs (T Cell Receptors). Such response generates intracellular antigen
processing which are highly selective and binds only to some of the numerous
polymorphic MHC class I molecules and often-impaired expression of MHC class I
on tumor cells. Human gamma delta T cells are MICA
(MHC-Class-Ipolypeptide-Related sequence-A) and MICB
(MHC-Class-Ipolypeptide-Related sequence-B), which are distantly related to MHC
class I but are functionally distinct. These molecules have no role in the
presentation of intracellular peptide antigens instead MICA and MICB are closely related
and functionally indistinguishable . The MHC class I molecules play important [...] |
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References:
1. gammadelta T cells link innate and adaptive immune responses.Holtmeier W, Kabelitz DChem Immunol Allergy. 20052. The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions.Sconocchia G, Lau M, Provenzano M, Rezvani K, Wongsena W, Fujiwara H, Hensel N, Melenhorst J, Li J, Ferrone S, Barrett AJ.Blood. 2005 Nov 15;106(10):3666-72. Epub 2005 Jul 26.
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