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Shedding of MICA-B Antigens

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Description

T cell responses against tumors require the recognition of specific peptides derived from tumor antigens in association with MIC (MHC Class I Molecules) by CD81 T cells expressing TCRs (T Cell Receptors). Such response generates intracellular antigen processing which are highly selective and binds only to some of the numerous polymorphic MHC class I molecules and often-impaired expression of MHC class I on tumor cells. Human gamma delta T cells are MICA (MHC-Class-Ipolypeptide-Related sequence-A) and MICB (MHC-Class-Ipolypeptide-Related sequence-B), which are distantly related to MHC class I but are functionally distinct. These molecules have no role in the presentation of intracellular peptide antigens instead MICA and MICB are closely related and functionally indistinguishable . The MHC class I molecules play important [...]

References:

1.gammadelta T cells link innate and adaptive immune responses.
Holtmeier W, Kabelitz D
Chem Immunol Allergy. 2005
2.The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions.
Sconocchia G, Lau M, Provenzano M, Rezvani K, Wongsena W, Fujiwara H, Hensel N, Melenhorst J, Li J, Ferrone S, Barrett AJ.
Blood. 2005 Nov 15;106(10):3666-72. Epub 2005 Jul 26.
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