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Shigella Invasion

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Bacterial pathogens possess highly specialized adaptive processes that enable their penetration of the host intestinal epithelium and cause disease. Once bound to the epithelial surface, bacteria may colonize and establish a permanent residence in the gut. Some Gram-negative pathogenic bacteria have acquired sophisticated molecular syringes , such as Type-III or Type-IV secretion systems, which are multisubunit molecular machines that span the bacterial and host membranes and translocate effectors directly into host cells. Shigella flexneri is a gram-negative facultative intracellular pathogen causing disease by invading the colonic mucosa. When Shigella reaches the colon, the bacteria are translocated through the epithelial barrier by way of the M-Cells of the Peyer s patches, which overlay the solitary lymphoid nodules. M-Cells allow intact S. flexneri to [...]


1.Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells.
Philpott DJ, Yamaoka S, Israel A, Sansonetti PJ
J Immunol. 2000 Jul 15; 165(2):903-14.
2.Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells.
Suzuki T, Mimuro H, Miki H, Takenawa T, Sasaki T, Nakanishi H, Takai Y, Sasakawa C.
J Exp Med. 2000 Jun 5; 191(11):1905-20.
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