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Shigella Invasion

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Description

Bacterial pathogens possess highly specialized adaptive processes that enable their penetration of the host intestinal epithelium and cause disease. Once bound to the epithelial surface, bacteria may colonize and establish a permanent residence in the gut. Some Gram-negative pathogenic bacteria have acquired sophisticated molecular syringes , such as Type-III or Type-IV secretion systems, which are multisubunit molecular machines that span the bacterial and host membranes and translocate effectors directly into host cells. Shigella flexneri is a gram-negative facultative intracellular pathogen causing disease by invading the colonic mucosa. When Shigella reaches the colon, the bacteria are translocated through the epithelial barrier by way of the M-Cells of the Peyer s patches, which overlay the solitary lymphoid nodules. M-Cells allow intact S. flexneri to [...]

References:

1.Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells.
Philpott DJ, Yamaoka S, Israel A, Sansonetti PJ
J Immunol. 2000 Jul 15; 165(2):903-14.
2.Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells.
Suzuki T, Mimuro H, Miki H, Takenawa T, Sasaki T, Nakanishi H, Takai Y, Sasakawa C.
J Exp Med. 2000 Jun 5; 191(11):1905-20.
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