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Description |
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Bacterial pathogens possess highly specialized adaptive processes that enable
their penetration of the host intestinal epithelium and cause disease. Once
bound to the epithelial surface, bacteria may colonize and establish a permanent
residence in the gut. Some Gram-negative pathogenic bacteria have acquired
sophisticated molecular syringes , such as Type-III or Type-IV secretion
systems, which are multisubunit molecular machines that span the bacterial and
host membranes and translocate effectors directly into host cells. Shigella
flexneri is a gram-negative facultative intracellular pathogen causing
disease by invading the colonic mucosa. When Shigella reaches the
colon, the bacteria are translocated through the epithelial barrier by way of
the M-Cells of the Peyer s patches, which overlay the solitary lymphoid nodules.
M-Cells allow intact S. flexneri to [...] |
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References:
1. Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells.Philpott DJ, Yamaoka S, Israel A, Sansonetti PJJ Immunol. 2000 Jul 15; 165(2):903-14.2. Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells.Suzuki T, Mimuro H, Miki H, Takenawa T, Sasaki T, Nakanishi H, Takai Y, Sasakawa C.J Exp Med. 2000 Jun 5; 191(11):1905-20.
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