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Signaling Involved in Cardiac Hypertrophy

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Myocardial hypertrophy is an adaptational response of the heart to increased work load, but it is also associated with a high risk of cardiac mortality due to its established role in the development of cardiac failure, one of the leading causes of death in developed countries (Ref.1). The hypertrophic growth of the myocardium is initiated by a wide array of endocrine, paracrine, and autocrine growth factors in response to biomechanical stress, increased workload, injury, or, intrinsic defects in contractile performance. Cardiac hypertrophy eventually normalizes the increase in wall tension, thereby abrogating the initial stimulus. Although initially beneficial, sustained cardiac hypertrophy can lead to decompensation and cardiomyopathy, the leading predictors of heart failure and sudden death in humans. The defining features [...]


1.Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes.
Wettschureck N, Rutten H, Zywietz A, Gehring D, Wilkie TM, Chen J, Chien KR, Offermanns S.
Nat Med. 2001 Nov; 7(11): 1236-40.
2.Calcineurin and beyond: cardiac hypertrophic signaling.
Molkentin JD
Circ Res. 2000 Oct 27; 87(9): 731-8. Review.
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