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Sphingolipid Metabolism and Apoptosis

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


The Golgi occupies a key position in the secretory membrane system of cells. Its most fundamental task is to act as a filter between the glycerolipid-rich ER (Endoplasmic Reticulum) and sterol/sphingolipid-rich plasma membrane. The cis-Golgi network, also called ER-Golgi intermediate compartment, forms the site where ER-derived cargo is received and it also provides a major site for the budding of vesicles mediating retrograde transport of selected proteins and lipids from the Golgi back to the ER. As cargo moves through the stack, it is modified by Golgi-associated processing enzymes, which include numerous glycosidases and glycosyltransferases. Positioned at the trans-side of the Golgi stack is the trans-Golgi network where, processed cargo is sorted, packaged into distinct vesicles, and shipped to various [...]


1.The organizing potential of sphingolipids in intracellular membrane transport.
Holthuis JC, Pomorski T, Raggers RJ, Sprong H, Van Meer G.
Physiol Rev. 2001 Oct; 81(4):1689-723. Review.
2.De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
Merrill AH Jr.
J Biol Chem. 2002 Jul 19; 277(29):25843-6. Epub 2002 May 13. Review.
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