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Ste20-PAK Signaling in Budding Yeast

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Protein kinases of the PAK (p21-Activated Kinase) family are found in all eukaryotic species. This family is defined by sequence similarity in the kinase domains and by the occurrence of a domain that can be bound by CDC42, a p21 GTPase of the Ras superfamily. Saccharomyces cerevisiae cells contain three members of this family, Ste20, Cla4, and Skm1, each of which performs a distinct set of cellular roles. Like all members of the PAK family, these three kinases contain an N-terminal PBD and a C-terminal protein kinase domain; however, Cla4 and Skm1 also contain a PH domain N-terminal to the PBD and, together with PAK2 from Schizosaccharomyces pombe, form a distinct subfamily (Ref.1).

The Ste20 group kinases are further divided into [...]


1.Yeast signal transduction: regulation and interface with cell biology.
Sprague GF, Cullen PJ, Goehring AS.
Adv Exp Med Biol. 2004; 547:91-105. Review.
2.Identification of p21-activated kinase specificity determinants in budding yeast: a single amino acid substitution imparts Ste20 specificity to Cla4.
Keniry ME, Sprague GF Jr.
Mol Cell Biol. 2003 Mar; 23(5):1569-80.
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