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Description |
Protein kinases of the PAK (p21-Activated Kinase) family are found in all
eukaryotic species. This family is defined by sequence similarity in the kinase
domains and by the occurrence of a domain that can be bound by CDC42, a p21
GTPase of the Ras superfamily. Saccharomyces cerevisiae cells
contain three members of this family, Ste20, Cla4, and Skm1, each of which
performs a distinct set of cellular roles. Like all members of the PAK family,
these three kinases contain an N-terminal PBD and a C-terminal protein kinase
domain; however, Cla4 and Skm1 also contain a PH domain N-terminal to the PBD
and, together with PAK2
from Schizosaccharomyces pombe, form a distinct subfamily
(Ref.1).
The Ste20 group kinases are further divided into [...] |
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References:
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