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Steroidogenesis in X. laevis Ovary

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Ovarian sex steroid production is essential for Follicular growth and subsequent Ovulation in Xenopus laevis. In the Xenopus ovary, Oocytes are arrested in an immature form in the Cell Cycle at Prophase-I boundary of the first meiotic cycle, and grow to their maximal size. Prophase-I arrest is terminated by specific signals, often Steroid Hormones, that cause release from Cell Cycle arrest and induce progression  of the Meiotic Cell Cycles to an arrest point during the second Meiotic division, often at Metaphase-II. This process, referred to as “Oocyte Maturation” transforms the immature Oocyte into a fertilizable egg. Two Steroid Hormones: Progesterone and Androgens are the primary mediators of Xenopus oocyte maturation. These hormones are synthesized in the Ovary itself, at the [...]


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