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TCR Signaling

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Description

T-Cells are a subset of lymphocytes that play a large role in the immune response. The TCR (T-Cell Receptor) is a complex of integral membrane proteins that participates in the activation of T-Cells in response to the presentation of antigen. Stimulation of TCR is triggered by MHC (Major Histocompatibility Complex) molecules on Antigen Presenting Cells that present antigen peptides to TCR complexes and induce a series of intracellular signaling cascades. Engagement of the TCR initiates positive (signal-enhancing) and negative (signal-attenuating) cascades that ultimately result in cellular proliferation, differentiation, cytokine production, and/or activation-induced cell death. These signaling cascades regulate T-Cell development, homeostasis, activation, acquisition of effector’s functions and apoptosis (Ref.1 & 2).

TCR is composed of six different chains that form [...]

References:

1.T cell receptor signaling.
Lin J, Weiss A.
J Cell Sci. 2001 Jan; 114(Pt 2): 243-4.
2.Phosphoinositide 3-kinase in T cell activation and survival.
Okkenhaug K, Bilancio A, Emery JL, Vanhaesebroeck B.
Biochem Soc Trans. 2004 Apr;32(Pt 2):332-5. Review.
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