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TGF-Beta Pathway

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Description

Cell proliferation in somatic tissues, specification of cell fate during embryogenesis, differentiation and cell death are controlled by a multitude of cell–cell signals and loss of this control has devastating consequences. Prominent among these regulatory signals is the TGF-Beta (Transforming Growth Factor) super family, which comprises a large and diverse group of polypeptide morphogens including the prototype of the family–the TGF-Beta themselves as well as the BMPs (Bone Morphogenetic Proteins), and the GDFs (Growth and Differentiation Factors) (Ref.1). The members of the TGF-Beta family are expressed in distinct temporal and tissue-specific patterns and therefore play an important role in the development, homeostasis and repair of most tissues in organisms. All immune cell lineages, including B-Cell, T-Cell and dendritic cells as [...]

References:

1.Transforming growth factor-beta isoforms and the induction of bone formation: implications for reconstructive craniofacial surgery.
Ripamonti U, Ferretti C, Teare J, Blann L.
J Craniofac Surg. 2009 Sep;20(5):1544-55.
2.Regulation of TGF-beta signaling by Smad7.
Yan X, Liu Z, Chen Y.
Acta Biochim Biophys Sin (Shanghai). 2009 Apr;41(4):263-72.
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