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TH17 Pathway

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T cells acts as a workhorse for the adaptive immune system, with the job of orchestrating defences against microbial invasion. A subcategory of T cells, T helper cells, defends against microbes, also causes trouble by inducing inflammation in immune-mediated diseases. T helper cells become further specialized, or differentiated, and a type known as TH17 has recently stepped into the limelight. These cells produce a messenger molecule called IL-17 (Interleukin-17), and are notable both in providing defence against extracellular bacteria and in mediating inflammation. TH17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease (Ref.1 & 2). Since CD4+ TH (T helper) cells are essential regulators of adaptive immune responses and inflammatory diseases. After [...]


1.Immunology: what does it mean to be just 17?
Tato CM, O'Shea JJ.
Nature. 2006 May 11;441(7090):166-8.
2.Development, cytokine profile and function of human interleukin 17-producing helper T cells.
Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F, Lecron JC, Kastelein RA, Cua DJ, McClanahan TK, Bowman EP, de Waal Malefyt R.
Nat Immunol. 2007 Sep;8(9):950-7. Epub 2007 Aug 5.
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