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Description |
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TLRs (Toll-like receptors) are key molecules of the innate immune system that recognize molecular patterns on microorganisms and rapidly alert the host to the presence of potentially dangerous organisms. When TLRs on the surface of an immune cell are engaged, two major events are triggered downstream. First, all TLRs trigger the secretion of intercellular messenger proteins called cytokines, which initiate and perpetuate inflammation. In most cases, the production of inflammatory cytokines in response to TLR stimulation depends on a common molecular pathway that is anchored by an adaptor protein MyD88 (Myeloid Differentiation Primary Response Gene 88). This protein contains a structural region called a TIR (Toll/Interleukin-1 Receptor) domain, which allows it to associate with the intracellular tail of a TLR [...] |
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