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TNF Superfamily Pathway

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TNF superfamily proteins consisting of 19 members that signal through 29 receptors. These ligands, while regulating normal functions such as immune responses, haematopoiesis and morphogenesis, have also been implicated in tumorigenesis,transplant rejection, septic shock, viral replication, bone resorption, rheumatoid arthritis and diabetes; so indicating their role as ‘double-edged swords’. These cytokines either induce cellular proliferation, survival, differentiation or apoptosis. The 19 ligands mediate their cellular response through 29 receptors that belong to the TNF receptor (TNFR) superfamily, and they are characterized by the presence of a cysteine-rich domain (CRD) in the extracellular portion (Ref.1 and 2).Based upon their cytoplasmic sequences and signaling properties, these TNF receptors can be classified into three major groups (Ref.1). The first group, including Fas/ CD95/ [...]


1.Looking beyond death: a morphogenetic role for the TNF signalling pathway.
Mathew SJ, Haubert D, Krönke M, Leptin M.
J Cell Sci. 2009 Jun 15;122(Pt 12):1939-46.
2.Signalling pathways of the TNF superfamily: a double-edged sword.
Aggarwal BB.
Nat Rev Immunol. 2003 Sep;3(9):745-56. Review.
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