This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
|
|
Description |
|
Various lipid molecules serve as second messengers for transducing signals from
the cell surface to the cell interior and trigger specific cellular responses.
Recently, several sphingolipids have emerged as cellular constituents that are
able to promote, mediate or counterbalance apoptosis. Sphingolipids are a family
of membrane lipids whose structure is made up of a long-chain sphingoid base
backbone (such as sphingosine), an amide-linked fatty acid of varying chain and
one of various polar head groups (hydroxyl for ceramide, phosphorylcholine for
sphingomyelin, and carbohydrate residues for glycosphingolipids). Addition of a
phosphocholine substituent or sugar to ceramide gives rise to the major
sphingolipid SM (sphingomyelin) or to glycosphingolipids. Ceramide is also
produced by breakdown of all sphingolipids by glycosidases and sphingomyelinases
(Smases; [...] |
|
|
References:
1. Enzymes of sphingolipid metabolism: from modular to integrative signaling.Hannun YA, Luberto C, Argraves KMBiochemistry. 2001 Apr 24; 40(16):4893-903. Review.2. Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice.Kreder D, Krut O, Adam-Klages S, Wiegmann K, Scherer G, Plitz T, Jensen JM, Proksch E, Steinmann J, Pfeffer K, Kronke M.EMBO J. 1999 May 4; 18(9):2472-9.
|
|
|
|
|