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TNF-Induced Apoptosis Implicating Sphingolipids

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Various lipid molecules serve as second messengers for transducing signals from the cell surface to the cell interior and trigger specific cellular responses. Recently, several sphingolipids have emerged as cellular constituents that are able to promote, mediate or counterbalance apoptosis. Sphingolipids are a family of membrane lipids whose structure is made up of a long-chain sphingoid base backbone (such as sphingosine), an amide-linked fatty acid of varying chain and one of various polar head groups (hydroxyl for ceramide, phosphorylcholine for sphingomyelin, and carbohydrate residues for glycosphingolipids). Addition of a phosphocholine substituent or sugar to ceramide gives rise to the major sphingolipid SM (sphingomyelin) or to glycosphingolipids. Ceramide is also produced by breakdown of all sphingolipids by glycosidases and sphingomyelinases (Smases; [...]


1.Enzymes of sphingolipid metabolism: from modular to integrative signaling.
Hannun YA, Luberto C, Argraves KM
Biochemistry. 2001 Apr 24; 40(16):4893-903. Review.
2.Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice.
Kreder D, Krut O, Adam-Klages S, Wiegmann K, Scherer G, Plitz T, Jensen JM, Proksch E, Steinmann J, Pfeffer K, Kronke M.
EMBO J. 1999 May 4; 18(9):2472-9.
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