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TNFR1 Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


The Tumor Necrosis Factor Receptor (TNFR) super family represents a growing family, with over 20 members having been identified so far in mammalian cells. TNF-Alpha (Tumor Necrosis Factor-Alpha), a potent cytokine, elicits a broad spectrum of biologic responses, which are mediated by binding to a cell surface receptor. TNF has been considered as an anti-cancer agent. Members of the TNFR superfamily can send both survival and death signals to cells. TNF family members play important roles in various physiological and pathological processes, including cell proliferation, differentiation, apoptosis and modulation of immune responses and induction of inflammation. TNF acts through two receptors, TNFR1 and TNFR2. TNFR1 is expressed by all human tissues and is the major signaling receptor for TNF-Alpha. TNFR2 [...]


1.Signal transduction by tumor necrosis factor and its relatives
Baud V, Karin M.
Trends Cell Biol 2001 Sep; 11(9):372-7.
2.Osmotic stress sensitizes naturally resistant cells to TNF- -induced apoptosis
D L Franco, I M Nojek, L Molinero, O A Coso, M A Costas
Cell Death and Differentiation 9, 1090 - 1098 (01 Oct 2002)
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