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TNFR2 Pathway

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Description

TNF (Tumor Necrosis Factor) family members play important roles in various physiological and pathological processes, including cell proliferation, differentiation, apoptosis, modulation of immune responses and induction of inflammation. TNF acts through two receptors, TNFR1 and TNFR2 (Tumor Necrosis Factor Receptors). TNFR1 is expressed by all human tissues and is the major signaling receptor for TNF-Alpha. TNFR2 is mostly expressed in immune cells and mediates limited biological responses (Ref.1). The 75-kDa TNFR2 transduces extracellular signals via receptor-associated cytoplasmic proteins. TNFR2 binds both TNF-Alpha and TNF-Beta. TNF-Beta is produced by activated lymphocytes and can be cytotoxic to many tumor and other cells. In neutrophils, endothelial cells and osteoclasts TNF-Beta can lead to activation while in many other cell types it can lead [...]

References:

1.Modulation of life and death by the TNF receptor superfamily.
Baker SJ, Reddy EP
Oncogene. 1998 Dec 24;17(25):3261-70
2.Physical mapping and genomic structure of the human TNFR2 gene
Beltinger, C. P. et al.
Genomics 35: 94-100, 1996.
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