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TOB in Osteoblast Signaling

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TOB (Transducer of ErbB2), a member of the TOB and BTG (B-cell Translocation Gene) anti-proliferative protein family, negatively regulates the proliferation of Osteoblasts (Ref.1). Bone is formed and resorbed continuously, starting in the embryo and continuing throughout adult life. This process occurring in adult bone is called bone remodeling. Bone remodeling is accomplished by precise coordination of two cell types, Osteoblasts and Osteoclasts (Ref.2). Osteoblasts deposit calcified bone matrix, and Osteoclasts resorb it. Deregulation of bone remodeling leads to metabolic bone disease. Osteoporosis, for example, is characterized by reduced bone mass and it results from an imbalance between bone formation and resorption. Therefore, bone remodeling needs a proper regulatory mechanism. Bone formation, a direct outcome of Osteoblast proliferation and differentiation, [...]


1.Identification of the Anti-proliferative protein Tob as a MAPK substrate.
Maekawa M, Nishida E, Tanoue T.
J Biol Chem. 2002 Oct 4;277(40):37783-7. Epub 2002 Jul 31.
2.Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda M, Noda T, Yamamoto T.
Cell. 2000 Dec 22;103(7):1085-97.
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