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TOR Complexes in Yeast

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Description

TOR (Target of Rapamycin) is a PIKK (Phosphatidylinositol Kinase-related protein Kinase) that controls cell growth and proliferation. In all eukaryotic cells expressing the protein, TOR function is controlled by nutrient availability, which ensures that protein synthesis is repressed when the supply of precursor amino acids is insufficient. In mammalian cells, one branch of this pathway controls general translational initiation, whereas a separate branch specifically regulates the translation of r-protein (ribosomal protein) mRNAs. In simple organisms, nutrient availability appears to be the major factor influencing TOR activity. In budding yeast, Saccharomyces cerevisiae the TOR pathway similarly regulates general translational initiation, but its specific role in the synthesis of ribosomal components is not well understood. In addition to general effects on translational [...]

References:

1.The TOR signaling cascade regulates gene expression in response to nutrients.
Cardenas ME, Cutler NS, Lorenz MC, Di Como CJ, Heitman J
Genes Dev. 1999 Dec 15; 13(24):3271-9.
2.TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.
Jacinto E, Guo B, Arndt KT, Schmelzle T, Hall MN.
Mol Cell. 2001 Nov; 8(5):1017-26.
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