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TRAF Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


The structural and metabolic integrity of bone is maintained through the dynamic process of bone remodeling that results from the coordinate action of bone resorption and the formation of new bone by osteoblasts. Regulation of bone remodeling occurs through multiple mechanisms that ultimately converge on the interaction of osteoclasts or their precursors with osteoblasts and bone marrow stromal cells. Two key factors supplied by the stromal environment are CSF1 (Colony-Stimulating Factor-1) and the TNF family member, RANKL (Receptor Activator of Nuclear Factor-KappaB Ligand, also called TRANCE, ODF, OPGL). Signaling through RANK is essential for the differentiation and activation of osteoclasts, the cell principally responsible for bone resorption. RANK provokes biochemical signaling via the recruitment of intracellular adaptor TRAFs (TNF [Tumor Necrosis Factor] Receptor-Associated Factors) after ligand binding and receptor oligomerization [...]


1.A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function.
Armstrong AP, Tometsko ME, Glaccum M, Sutherland CL, Cosman D, Dougall WC.
J Biol Chem. 2002 Nov 15; 277(46): 44347-56.
2.TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.
Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE.
J Biol Chem. 1999 Oct 15; 274(42): 30202-8.
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