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TWEAK Pathway

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Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor (TNF) superfamily (TNFSF) that is induced in a variety of cell types in situations of tissue injury. It is expressed in various tissues including the intestine, pancreas, lung, brain, skeletal muscle, heart and vasculature. The 249 amino acid-comprising membrane-bound form of TWEAK consists extracellularly of the characteristic C-terminally located TNF homology domain (THD), which is separated from the transmembrane domain by a stalk region of about 55 amino acids. It can be cleaved by furin endoprotease into a soluble TWEAK (sTWEAK) (185 aa, 18 kDa) which then binds to the Fibroblast growth factor-inducible 14 (Fn14) receptor on the cell, the cognate receptor [...]


1.TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner.
Yang B, Yan P, Gong H, Zuo L, Shi Y, Guo J, Guo R, Xie J, Li B.
Am J Transl Res. 2016 Sep 15;8(9):3848-3860. eCollection 2016.
2.The TWEAK-Fn14 system as a potential drug target.
Wajant H.
Br J Pharmacol. 2013 Oct;170(4):748-64. doi: 10.1111/bph.12337. Review.
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