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TWEAK Pathway

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TWEAK is a cell surface-associated type II transmembrane protein (249-amino acid) belonging to the TNF (Tumor Necrosis Factor) superfamily. The protein was named TWEAK for its relatedness to TNF and its weak apoptotic ability. The predicted cytoplasmic, transmembrane and extracellular domains of TWEAK consist of amino acids 1-18, 19-42, and 43-249, respectively. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, and under some experimental conditions, stimulation of apoptosis.TWEAK functions as a novel pathogenic mediator by amplifying inflammation, promoting tissue damage and potentially impeding endogenous repair mechanisms. It is produced by IFN-gamma-stimulated monocytes and induces multiple pathways of cell death, including Caspase-dependent apoptosis,Cathepsin-B-dependent necrosis, and endogenous TNF-Alpha-mediated cell death, in a cell type-specific [...]


1.TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease.
Burkly LC, Michaelson JS, Hahm K, Jakubowski A, Zheng TS.
Cytokine. 2007 Oct;40(1):1-16. Epub 2007 Nov 5. Review.
2.TWEAK is expressed at the cell surface of monocytes during multiple sclerosis.
Desplat-J├ęgo S, Feuillet L, Creidy R, Malikova I, Rance R, Khrestchatisky M, Hahm K, Burkly LC, Pelletier J, Boucraut J.
J Leukoc Biol. 2009 Jan;85(1):132-5. Epub 2008 Oct 22.
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