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Tec Kinases Signaling

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Nonreceptor PTKs (Protein Tyrosine Kinases) are essential for the development and activation of B-Cells and T-Cells (Ref.1). The Tec kinases represent the second largest family of mammalian non-RTKs (Receptor Tyrosine Kinases), which are activated in blood cells by stimulation of Cytokine Receptors, Lymphocyte surface antigens, GPCR (G-Protein Coupled Receptors), receptor type PTKs, or Integrins (Ref.2). Tec family members include Tec, BTK (Bruton’s Tyrosine Kinase), ITK (IL-2-Inducible T-cell Kinase)/ EMT/TSK, BMX (Bone Marrow Kinase)/ETK (Epithelial and Endothelial Tyrosine Kinase) and RLK (Resting Lymphocyte Kinase)/TXK. Expression of most Tec kinases is restricted to hematopoietic cells and play important roles in the development or maintenance of the hematopoietic system. Tec, the founding member of the Tec kinase family, is expressed in T-Cells and B-Cells, myeloid cells, and in liver. It is activated in response to BCR (B-Cell Receptor), TCR (T-Cell Receptor)/CD28 [...]


1.Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity.
Middendorp S, Dingjan GM, Maas A, Dahlenborg K, Hendriks RW.
J Immunol. 2003 Dec 1;171(11):5988-96.
2.Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1.
Yoshida K, Yamashita Y, Miyazato A, Ohya K, Kitanaka A, Ikeda U, Shimada K, Yamanaka T, Ozawa K, Mano H.
J Biol Chem. 2000 Aug 11; 275(32): 24945-52.
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