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Telomere Extension in Yeast

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Description

Telomeres are specialized nucleoprotein structures found at the ends of linear eukaryotic chromosomes. Telomeres confer stability to chromosomes by preventing nucleolytic degradation and recombination. They also function in chromosomal localization, nuclear architecture, and repression of nearby genes. The telomeric DNA of most organisms consists of simple tandem repeats that are rich in dG and dT residues on the 3 end-containing strand. This strand is synthesized by a ribonucleoprotein complex called telomerase, an enzyme that is critical to the maintenance of telomere length and function (Ref.1).

The telomeres of the budding yeast Saccharomyces cerevisiae contain ~300 base pairs of double-stranded (TG1-3/C1-3A) sequences. Telomerase recruitment is mediated by a direct protein-protein interaction between CDC13 and the telomerase-associated EST1 and EST2 protein. In the absence [...]

References:

1.Identification and characterization of a telomerase activity from Schizosaccharomyces pombe.
Lue NF, Peng Y.
Nucleic Acids Res. 1997 Nov 1; 25(21): 4331-7.
2.Involvement of replicative polymerases, Tel1p, Mec1p, Cdc13p, and the Ku complex in telomere-telomere recombination.
Tsai YL, Tseng SF, Chang SH, Lin CC, Teng SC.
Mol Cell Biol. 2002 Aug; 22(16): 5679-87.
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