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Thalassemia is one of the most deadly inherited blood disorders, characterized by abnormal production of hemoglobin and excessive destruction of red blood cells. It is a single-gene disorder that is passed from parents to child by autosomal recessive pattern of inheritance. Progressive iron overload and Anemia are the most salient and ultimately fatal complications of Thalassemia. According to the type of globin polypeptide chain that is underproduced, Thalassemia is generally classified into 3 major types: Alpha, Beta and Delta thalassemia, Beta thalassemia being the most fetal one. Globin protein is the main constituent of hemoglobin, which is a globular protein that consists of two Alpha and two Beta globin polypeptide chains, where each globin chain is associated with a heme [...]


1.Thalassemia and hypercoagulability.
Taher AT, Otrock ZK, Uthman I, Cappellini MD.
Blood Rev. 2008 Sep;22(5):283-92. Epub 2008 Jun 3. Review.
2.Regulation of human alpha-globin gene expression and alpha-thalassemia.
Ribeiro DM, Sonati MF.
Genet Mol Res. 2008 Oct 14;7(4):1045-53.
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