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Threonine Metabolism in H. hepaticus

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H. hepaticus (Helicobacter hepaticus) are motile and Gram-negative, curved to spiral in shape, with one to several spirals; and it has bipolar sheathed flagella (one at each end) but lacks the periplasmic fibers that envelope the bacterial cells in other mouse Helicobacter species. It grows microaerobically at 37ºC but not at 25ºC or 42ºC. H. hepaticus colonize in the large intestine and then translocate to the liver and colonize in the biliary system in mice and thereby cause chronic Hepatitis and liver cancer. It is the prototype enterohepatic Helicobacter species and a close relative of H. pylori (Helicobacter pylori), also a recognized carcinogen. H. hepaticus have a circular chromosome encoding 1,875 proteins. A total of 938, 953, and 821 proteins [...]


1.The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus.
Suerbaum S, Josenhans C, Sterzenbach T, Drescher B, Brandt P, Bell M, Droge M, Fartmann B, Fischer HP, Ge Z, Horster A, Holland R, Klein K, Konig J, Macko L, Mendz GL, Nyakatura G, Schauer DB, Shen Z, Weber J, Frosch M, Fox JG.
Proc. Natl. Acad. Sci. U S A. 2003 Jun 24;100(13):7901-6.
2.Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice.
Ge Z, Feng Y, Whary MT, Nambiar PR, Xu S, Ng V, Taylor NS, Fox JG.
Infect. Immun. 2005 Jun;73(6):3559-67.
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