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Threonine Metabolism in H. pylori 26695

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The Gram-negative, micro-aerophilic, spiral-shaped and flagellated bacteria, H. pylori (Helicobacter pylori) are associated with the pathogenesis of Gastric inflammation and Peptic ulcer disease. Presence of H. pylori in the gastric mucosa is associated with Gastritis and is often implicated in Peptic ulceration and Mucosa-associated lymphoid tissue Lymphomas. The H. pylori genome is important for drug discovery and vaccine development and this is exemplified by the genome analysis of H. pylori Strain 26695 (Ref.1). H. pylori 26695 protein-coding genes (1,590 genes) are unique to the strain. H. pylori have well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. H. pylori utilize amino acids as the sole carbon and nitrogen energy source. It also utilizes Glucose. Amino acids [...]


1.Genome-scale metabolic model of Helicobacter pylori 26695.
Schilling CH, Covert MW, Famili I, Church GM, Edwards JS, Palsson BO.
J. Bacteriol. 2002 Aug;184(16):4582-93.
2.Helicobacter pylori: current status and future prospects.
O'Mahony R, Vaira D, Holton J, Basset C.
Sci. Prog. 2004;87(Pt 4):269-96.
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