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Threonine Metabolism in H. pylori J99

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The H. pylori (Helicobacter pylori) J99 strains are Gram-negative, micro-aerophilic, spiral-shaped and flagellated bacteria, are associated with the pathogenesis of Gastric inflammation and Peptic ulcer disease (Ref.1). Presence of H. pylori J99 in the gastric mucosa is associated with Duodenal ulcers. The H. pylori genome is important for drug discovery and vaccine development and this is exemplified by the genome analysis of not only H. pylori Strain 26695 but also H. pylori J99. H. pylori J99 protein-coding genes (91 genes) are unique to the strain. H. pylori have well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. H. pylori utilize amino acids as the sole carbon and nitrogen energy source. It also utilizes Glucose. Amino acids [...]


1.Th response to Helicobacter pylori differs between patients with gastric ulcer and duodenal ulcer.
Itoh T, Seno H, Kita T, Chiba T, Wakatsuki Y.
Scand. J. Gastroenterol. 2005 Jun;40(6):641-7.
2.Helicobacter pylori and complex gangliosides.
Roche N, Angstrom J, Hurtig M, Larsson T, Boren T, Teneberg S.
Infect. Immun. 2004 Mar;72(3):1519-29.
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