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Transcriptional Regulatory Network in Embryonic Stem Cell

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Stem Cells are undifferentiated cells that can give rise to several lineages of differentiated cell types. They are the founder cells for every organ, tissue and cell in the body. Stem cells are characterized by the ability to self-renew and maintain Pluripotency. These features allow Stem Cells to fulfill their multiple functions, namely to provide enough cells during organogenesis, to control tissue homeostasis and, in addition, to ensure regeneration and repair. ESCs (Embryonic Stem Cells) are derived from the ICM (Inner Cell Mass) of the developing Blastocysts, multicellular structures originating from four (Human) to five (Mouse) cleavages of fertilized oocytes. In Human, the fertilization of an Egg by a Sperm generates a Zygote that thirty hours later begins to divide. [...]


1.Differences between human and mouse embryonic stem cells.
Ginis I, Luo Y, Miura T, Thies S, Brandenberger R, Gerecht-Nir S, Amit M, Hoke A, Carpenter MK, Itskovitz-Eldor J, Rao MS.
Dev Biol. 2004 May 15;269(2):360-80.
2.Transcriptional regulation of nanog by OCT4 and SOX2.
Rodda DJ, Chew JL, Lim LH, Loh YH, Wang B, Ng HH, Robson P.
J Biol Chem. 2005 Jul 1;280(26):24731-7.
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