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Tumor Escape Mechanisms

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Description

Tumour cells characteristically provides their own growth signals, and ignore growth-inhibitory signals, avoid cell death, replicate without limits, sustain angiogenesis, and invade tissues through basement membranes and capillary walls. Where as cancer immunosurveillance predicts that the immune system can recognize precursors of cancer and, in most cases, destroy these precursors before they become clinically apparent. But sometimes tumour cells use to escape these innate and adaptive immune responses by immunoselection (that is, selection of non-immunogenic tumour-cell variants, a process that is also known as immunoediting) or by immunosubversion (that is, active suppression of the immune response) and heads towards a difficult situation which is refer as cancer.There are around eight types of tumour escape mechanisms which are as follows (Ref [...]

References:

1.Cancer despite immunosurveillance: immunoselection and immunosubversion.
Zitvogel L, Tesniere A, Kroemer G.
Nat Rev Immunol. 2006 Oct; 6(10):715-27. Epub 2006 Sep 15.
2.Tumor escape mechanisms in prostate cancer.
Miller AM, Pisa P.
Cancer Immunol Immunother. 2007 Jan;56(1):81-7. Epub 2005 Dec 16.
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