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UPA-Upar Pathway

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Description

Proteases are expressed by normal cells in tissue remodeling events and also during pathological events such as tumor invasion and metastasis. Some of the proteases including serine proteinases and MMPs (Metalloproteinases) have been implicated in remodeling of the ECM (Extracellular Matrix) in lung injury and lung neoplasia. These enzymes influence inflammatory cell traffic or cancer cell invasiveness via the breakdown of basement membranes and ECM. Plasmin, a serine protease, is involved in the dissolution of ECM and basement membrane during tissue degradation. This protease is generated via the action of plasminogen activators such as Urokinase (UPA, Urokinase-type Plasminogen Activator) or tPA (tissue Plasminogen Activator) and can influence tissue remodeling either directly or through activation of latent collagenases. Urokinase is mainly [...]

References:

1.Urokinase-type plasminogen activator induces tyrosine phosphorylation of a 78-kDa protein in H-157 cells.
Bhat GJ, Gunaje JJ, Idell S.
Am J Physiol. 1999 Aug; 277(2 Pt 1): L301-9.
2.Urokinase induces expression of its own receptor in Beas2B lung epithelial cells.
Shetty S, Idell S.
J Biol Chem. 2001 Jul 6; 276(27): 24549-56. Epub 2001 May 07.
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