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UVB-Induced MAPK Signaling

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UV (Ultraviolet) radiation is a naturally occurring genotoxic agent and is the primary environmental carcinogen responsible for the development of most skin Cancers. The UV portion of solar radiation is composed of UVC (200–280 nm), UVB (280–315 nm), and UVA (315–400 nm). Much of the important damage produced by solar radiation is caused by UVB fluences, which induce damage to a variety of cellular targets including DNA. In the case of DNA damage, UVB generates Oxygen radicals as well as inducing Cyclobutane pyrimidine dimers and Pyrimidine-Pyrimidone photoproducts. These forms of DNA damage, directly or indirectly, signals the activation of a series of signal transduction cascades comprised of serine/threonine kinases, MAPKs (Mitogen-Activated Protein Kinases). In addition, UV radiation rapidly triggers signal [...]


1.Functional genomics of UV radiation responses in human cells.
Koch-Paiz CA, Amundson SA, Bittner ML, Meltzer PS, Fornace AJ Jr.
Mutat Res. 2004 May 18;549(1-2):65-78.
2.Role of protein kinase Cdelta in UV-B-induced Apoptosis of macrophages in vitro.
Sodhi A, Sethi G.
Cell Signal. 2005 Mar;17(3):377-83.
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