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VEGF Pathway

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The formation of blood vessels occurs either by in situ differentiation of endothelial cell precursors (Angioblasts) and association of these cells to form primitive vessels, a process called Vasculogenesis, or by growth of preexisting vessels, a process called Angiogenesis. Vasculogenesis establishes the primary vascular plexus of the early embryo, whereas development of blood vessels during later embryogenesis and adult life occurs primarily by Angiogenesis. Angiogenesis is an integral feature of capillary sprouts from preexisting blood vessels. It is typically quiescent in the adult, except for pathological situations (e.g., wound healing, Diabetic Retinopathy, Rheumatoid Arthritis, Cardiac Ischemia, Psoriasis, tumor growth) and during menstrual cycle-specific physiological processes in the female reproductive system (e.g., ovulation, endometrial growth, implantation, placentation) (Ref.1 & 2). Once [...]


1.A review on angiogenesis and its assays.
Tahergorabi Z, Khazaei M.
Iran J Basic Med Sci. 2012 Nov;15(6):1110-26.
2.Vasculogenic cytokines in wound healing.
Wong VW, Crawford JD.
Biomed Res Int. 2013;2013:190486. doi: 10.1155/2013/190486. Epub 2013 Feb 28. Review.
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