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VEGF Pathway

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Description

The formation of blood vessels occurs either by in situ differentiation of endothelial cell precursors (Angioblasts) and association of these cells to form primitive vessels, a process called Vasculogenesis, or by growth of preexisting vessels, a process called Angiogenesis. Vasculogenesis establishes the primary vascular plexus of the early embryo, whereas development of blood vessels during later embryogenesis and adult life occurs primarily by Angiogenesis. Angiogenesis is an integral feature of capillary sprouts from preexisting blood vessels. It is typically quiescent in the adult, except for pathological situations (e.g., wound healing, Diabetic Retinopathy, Rheumatoid Arthritis, Cardiac Ischemia, Psoriasis, tumor growth) and during menstrual cycle-specific physiological processes in the female reproductive system (e.g., ovulation, endometrial growth, implantation, placentation) (Ref.1 & 2). Once [...]

References:

1.Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta.
Mueller MD, Vigne JL, Minchenko A, Lebovic DI, Leitman DC, Taylor RN.
Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20): 10972-7.
2.Vascular endothelial growth factor in the lung.
Voelkel NF, Vandivier RW, Tuder RM.
Am J Physiol Lung Cell Mol Physiol. 2006 Feb;290(2):L209-21.
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