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VEGF and S-1P Signaling

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Angiogenesis is important in embryonic development as well as in physiological events and dysregulated angiogenesis is involved in various pathological conditions, like solid tumor growth, Rheumatoid Arthritis, and Diabetic Retinopathy. Angiogenesis is initiated by vascular endothelial cells and involves their orderly proliferation, migration, and morphogenesis into new capillary networks. Such events are precisely regulated by soluble growth factors as well as endothelial cell–derived signals. Recently, S-1P (Sphingosine 1-Phosphate), a bioactive lipid released by activated platelets, has emerged as an important mediator of angiogenesis. S-1P induces migration, proliferation, and cytoskeletal changes of endothelial cell by binding to the EDG (Endothelial Differentiation Gene), a family of GPCR (G-Protein Coupled Receptors). In the EDG family, EDG1, EDG3, EDG5, EDG6, and EDG8 work as [...]


1.Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS).
Tanimoto T, Jin ZG, Berk BC.
J Biol Chem. 2002 Nov 8; 277(45):42997-3001. Epub 2002 Sep 10.
2.Regulation of angiogenesis via vascular endothelial growth factor receptors.
Veikkola T, Karkkainen M, Claesson-Welsh L, Alitalo K.
Cancer Res. 2000 Jan 15; 60(2):203-12.
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