PI3Ks (Phosphoinositide-3 Kinases) are heterodimeric lipid kinases that are composed of a regulatory and catalytic subunit that are encoded by different genes (Ref.1). Two distinct VPS34P (Vacuolar Protein-Sorting-34-PI3K (Phosphatidylinositde-3 Kinase)) complexes occur in S. cerevisiae (Saccharomyces cerevisiae) in order to carry out autophagy and CpY (Carboxypeptidase-Y) sorting. VPS34P is activated by VPS15P, a protein kinase. Of the two distinct VPS34P complexes; Complex-I, contains VPS15P, VPS30P/Apg6P (Autophagy Protein-Apg6) and Apg14P, functions in autophagy and the other, Complex-II contains VPS15P, VPS30P/Apg6P (Autophagy Protein-Apg6) and VPS38P which functions in CpY sorting. In general, VPS34P forms at least two multi-subunit PI3K complexes: both contain VPS15P and VPS30P/Apg6P, whereas Apg14P and VPS38P are specific to each. VPS15P-mediated phosphorylation controls binding of VPS34P to VPS38P and [...]