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VPS34-PI3K Signaling in Saccharomyces cerevisiae

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PI3Ks (Phosphoinositide-3 Kinases) are heterodimeric lipid kinases that are composed of a regulatory and catalytic subunit that are encoded by different genes (Ref.1). Two distinct VPS34P (Vacuolar Protein-Sorting-34-PI3K (Phosphatidylinositde-3 Kinase)) complexes occur in S. cerevisiae (Saccharomyces cerevisiae) in order to carry out autophagy and CpY (Carboxypeptidase-Y) sorting. VPS34P is activated by VPS15P, a protein kinase. Of the two distinct VPS34P complexes; Complex-I, contains VPS15P, VPS30P/Apg6P (Autophagy Protein-Apg6) and Apg14P, functions in autophagy and the other, Complex-II contains VPS15P, VPS30P/Apg6P (Autophagy Protein-Apg6) and VPS38P which functions in CpY sorting. In general, VPS34P forms at least two multi-subunit PI3K complexes: both contain VPS15P and VPS30P/Apg6P, whereas Apg14P and VPS38P are specific to each. VPS15P-mediated phosphorylation controls binding of VPS34P to VPS38P and [...]


1.The phosphatidylinositol 3-Kinase AKT pathway in human cancer.
Vivanco I, Sawyers CL.
Nat. Rev. Cancer. 2002 Jul;2(7):489-501.
2.Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.
Kihara A, Noda T, Ishihara N, Ohsumi Y.
J. Cell. Biol. 2001 Feb 5;152(3):519-30.
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