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Vav Signaling in T-Lymphocyte

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Description

Vav (Oncogene Vav) family of proteins act as GEFs (Guanine Nucleotide Exchange Factors) and activators of Rho family GTPases, and are known to orchestrate cytoskeletal changes and cell migration in response to extracellular stimuli by catalyzing the exchange of GDP for GTP. Of the three mammalian isoforms, Vav1 is primarily expressed in hematopoietic cells, while Vav2 and Vav3 are more ubiquitously expressed (Ref.1). Vav proteins are found in the cytoplasm of resting lymphocytes, and TCR (T Cell Receptor)/CD3 (CD3 Antigen) stimulation cause their translocation to the plasma membrane, presumably because of recruitment to either ZAP70 (Zeta-Chain-Associated Protein Kinase) or to the LAT (Linker for Activation of T-Cells)-SLP76 (SH2 Domain-Containing Leukocyte Protein-76) complex. Vav proteins are required for both positive and [...]

References:

1.Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization.
Wells CM, Bhavsar PJ, Evans IR, Vigorito E, Turner M, Tybulewicz V, Ridley AJ.
Exp. Cell Res. 2005 Nov 1;310(2):303-10.
2.Vav-family proteins in T-cell signalling.
Tybulewicz VL.
Curr. Opin. Immunol. 2005 Jun;17(3):267-74.
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