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WNT Signaling

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The development of tissues and organs in multicellular organisms is controlled by the interplay of several signaling pathways that cross talk to provide positional information and induce cell fate specification. Together with other families of secreted factors such as TGF-Betas (Transforming Growth Factor-Betas), FGFs (Fibroblast Growth Factors), Hedgehog and Notch proteins, WNT (Wingless-Type MMTV Integration Site Family) Growth Factors are crucially implicated in these processes. The WNT genes encode a large family of secreted protein growth factors that have been identified in animals from Hydra to Human. The name WNT denotes the relationship of this family to the Drosophila segment polarity gene Wg (Wingless) and to its vertebrate ortholog, Int1, a mouse protooncogene. At present, close to 100 WNT genes [...]


1.Winding through the WNT pathway during cellular development and demise.
Li F, Chong ZZ, Maiese K.
Histol Histopathol. 2006 Jan;21(1):103-24. Review.
2.Comparative genomics on Wnt5a and Wnt5b genes.
Katoh M, Katoh M.
Int J Mol Med. 2005 Apr;15(4):749-53.
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