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WNT Signaling in D. melanogaster

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The development of tissues and organs in multicellular organisms is controlled by the interplay of several signaling pathways that cross talk to provide positional information and induce cell fate specification. Together with other families of secreted factors such as TGF-Betas (Transforming Growth Factor-Betas), FGFs (Fibroblast Growth Factors), Hedgehog and Notch proteins, WNT (Wingless-Type MMTV Integration Site Family) Growth Factors are crucially implicated in these processes. The WNT genes encode a large family of secreted protein growth factors that have been identified in animals from hydra to human. The name WNT denotes the relationship of this family to the Drosophila segment polarity gene Wg (Wingless) and to its vertebrate ortholog, Int1, a mouse protooncogene. At present, close to 100 Wnt genes [...]


1.Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference.
Matsubayashi H, Sese S, Lee JS, Shirakawa T, Iwatsubo T, Tomita T, Yanagawa S.
Mol Cell Biol. 2004 Mar;24(5):2012-24.
2.Teaching resource. Canonical WNT/beta-catenin signaling.
Moon RT.
Sci STKE. 2004 Jun 29;2004(240):tr5.
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