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c-Myc and Apoptosis

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Many proto-oncogenes participate in the regulation of apoptosis and closely intertwined with their actions are various growth factors and other genes that participate in the control of cellular growth. The proto-oncogene c-Myc encodes a transcription factor c-Myc that plays a critical role in multiple cellular processes including cell growth, proliferation, differentiation, and apoptosis. Expression of c-Myc is rapidly induced by mitogens and is down regulated during differentiation. c-Myc activity is sufficient to drive cells into the cell cycle in the absence of growth factors but also induces apoptosis when survival factors are missing. Deregulated expression of c-Myc is associated with a wide array of human cancers. Thr-58 is a major phosphorylation site in c-Myc and is a mutational hotspot in [...]


1.MYC oncogenes and human neoplastic disease.
Nesbit CE, Tersak JM, Prochownik EV.
Oncogene. 1999 May 13; 18(19): 3004-16. Review.
2.c-Myc-induced sensitization to apoptosis is mediated through Cytochrome c release.
Juin P, Hueber AO, Littlewood T, Evan G.
Genes Dev. 1999 Jun 1; 13(11): 1367-81.
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