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cAMP Chemotaxis Pathway in D. discoideum

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Description

D. discoideum (Dictyostelium discoideum) is an accessible organism for studies of signaling via Chemoattractant Receptors. Many features of the pathways in mammalian leukocytes are similar to those in the model organism D. discoideum. Analysis of signaling processes in this amoeba has led to discoveries that have subsequently been confirmed in mammalian systems. Advantages of D. discoideum as a model organism include its genetic, biochemical and cell biological accessibility (Ref.1). The social amoebae D. discoideum has proven indispensable to elucidate signaling events that regulate Chemotaxis. In D. discoideum, cAMP (Cyclic Adenosine 3 ,5 -Monophosphate), Folic Acid as well as factors from Bacteria, serve as Chemoattractants. D. discoideum lives two independent life cycles: Vegetative or Growth-stage cells function independently and use phagocytosis or pinocytosis [...]

References:

1.The signal to move: D. discoideum go orienteering.
Kimmel AR, Parent CA.
Science. 2003 Jun 6;300(5625):1525-7.
2.Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved?
Bankir L, Ahloulay M, Devreotes PN, Parent CA.
Am. J. Physiol. Renal. Physiol. 2002 Mar;282(3):F376-92.
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