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cAMP Pathway

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cAMP (Cyclic Adenosine 3 ,5 -monophosphate) is the first identified second messenger, which has a fundamental role in the cellular response to many extracellular stimuli. The cAMP signaling pathway controls a diverse range of cellular processes. Indeed, not only did cAMP provide the paradigm for the second messenger concept, but also provided the paradigm for signaling compartmentalization. The different receptors, chiefly the GPCRs (G-Protein Coupled Receptors), Alpha and Beta-ADRs (Adrenergic Receptors), Growth Factor receptors, CRHR (Corticotropin Releasing Hormone Receptor), GcgR (Glucagon Receptor), DCC (Deleted in Colorectal Carcinoma), etc are responsible for cAMP accumulation in cells that cause different physiological outcomes, and changes in cAMP levels effects the selective activation of PKA (cAMP dependent Protein Kinase-A) isoforms. The chief source of cAMP is [...]


1.Sensitization of adenylate cyclase by Galpha i/o-coupled receptors.
Watts VJ, Neve KA.
Pharmacol. Ther. 2005 Jun;106(3):405-21.
2.Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa.
Jaiswal BS, Conti M.
Proc. Natl. Acad. Sci. U S A. 2003 Sep 16;100(19):10676-81.
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