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cAMP Signaling in C. neoformans

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C. neoformans (Cryptococcus neoformans) is a Basidiomycetous fungus and a significant human pathogen with worldwide distribution. Its importance as an opportunistic pathogen has increased in the past two decades, largely as a result of AIDS (Acquired Immune Deficiency Syndrome), cancer chemotherapy and immuno-suppression for organ transplants. Infections begin in the lung following inhalation of small, dessicated yeast cells or spores, both of which are small enough to fit into the alveoli of the lung. The organism then spreads via the blood to other organs, especially the CNS (Central Nervous System). Survival in the CNS is enhanced by the presence of abundant neurotransmitters that are scavenged as the diphenolic precursors to synthesize the virulence factor Melanin (Ref.1). Cryptococcal infection is now [...]


1.Investigation of the basis of virulence in serotype A strains of Cryptococcus neoformans from apparently immunocompetent individuals.
D'Souza CA, Hagen F, Boekhout T, Cox GM, Heitman J.
Curr. Genet. 2004 Aug;46(2):92-102.
2.Genetics of cryptococcus neoformans.
Hull CM, Heitman J.
Annu. Rev. Genet. 2002;36:557-615.
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