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cAMP Signaling in N. crassa

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The ascomycete N. crassa (Neurospora crassa) has defined asexual and sexual cycles. N. crassa is heterothallic and has two mating types, A and a. Under nutrient-rich conditions like Carbon, etc, N. crassa proliferates by the extension and branching of multinucleate vegetative hyphal cells to form a multicellular mycelium (Ref.1). In response to nutrient deprivation, desiccation and light, N. crassa initiates asexual conidiation. The major determinants regulating the onset of conidiation are the availability of Carbon source and light. The sexual cycle initiates in response to Nitrogen starvation. Heterotrimeric G-proteins play a critical role in regulating growth and differentiation in the filamentous fungi N. crassa. Filamentation, conidiation, morphogenesis, mating and stress tolerance in N. crassa are controlled by cAMP (Cyclic Adenosine [...]


1.A catalytic subunit of cyclic AMP-dependent protein kinase, PKAC-1, regulates asexual differentiation in Neurospora crassa.
Banno S, Ochiai N, Noguchi R, Kimura M, Yamaguchi I, Kanzaki S, Murayama T, Fujimura M.
Genes Genet. Syst. 2005 Feb;80(1):25-34.
2.Severe impairment of growth and differentiation in a Neurospora crassa mutant lacking all heterotrimeric G alpha proteins.
Kays AM, Borkovich KA.
Genetics. 2004 Mar;166(3):1229-40.
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